Anti-Phospho-MAP3K5-S1033 Polyclonal Antibody
品牌：solarbio | 货号：K006189P
| 英文名称 | Anti-Phospho-MAP3K5-S1033 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 别名 | ASK1;MAPKKK5;MEKK5 |
| 应用 | WB |
| 稀释比例 | WB 1:500-2000. |
| 交叉反应 | Human Mouse Rat |
| 蛋白分子量 | 155kDa |
| Gene ID | 4217 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A phospho specific peptide corresponding to residues surrounding S1033 of human MAP3K5 |
| 性状 | 液体 |
| Public Immunogen Range | A phospho specific peptide corresponding to residues surrounding S1033 of human MAP3K5 |
| Subcellular Locations | Cytoplasm Endoplasmic reticulum |
| Swiss Prot | Q99683 |
| 克隆类型 | Polyclonal Antibody |
| 背景资料 | Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. |