Anti-CD45 Monoclonal antibody
品牌：solarbio | 货号：K006380M
| 英文名称 | Anti-CD45 Monoclonal antibody |
|---|---|
| 宿主 | Mouse |
| 别名 | B220;CD45;CD45R;GP180;L-CA;LCA;LY5;T200 |
| 应用 | FCM |
| 稀释比例 | WB 1:500-2000. IHC 1:200-1000. |
| 交叉反应 | Human |
| Gene ID | 5788 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG1 |
| 免疫原 | Purified recombinant fragment of human PTPRC (AA: 928-989) expressed in E. Coli |
| 性状 | 液体 |
| Public Immunogen Range | Purified recombinant fragment of human PTPRC (AA: 928-989) expressed in E. Coli |
| Subcellular Locations | Membrane Membrane raft Single-pass type I membrane protein |
| Swiss Prot | P08575 |
| 克隆号 | 1E1-F11-E10 |
| 克隆类型 | Monoclonal antibody |
| 背景资料 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. |